Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Therefore, this study aims to examine the relationship between the PIN1 and eNOS genes expression, as well as serum levels and hypertension in Alzheimer's disease sufferers.
|
28506742 |
2017 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
No differences were observed in the distribution of G894T (Glu298Asp) NOS3 genotypes between the resistant hypertension group and the controlled hypertension patients.
|
19650939 |
2009 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
This study indicates that eNOS gene delivery in rats with renal failure improves NO release, which likely prevents the aggravation of hypertension and slows down the progression of renal failure and injury.
|
22121231 |
2012 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Second, an ANOVA was used to test the significance of an association between eNOS genotype and the level of blood pressure within the entire population except for 167 hypertensive subjects who had been under treatment for hypertension.
|
10205226 |
1999 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Salt intake affects the relation between hypertension and the T-786C polymorphism in the endothelial nitric oxide synthase gene.
|
16364825 |
2005 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
LHGDN |
Endothelial nitric oxide synthase genetic variation and essential hypertension risk in Han Chinese: the Fangshan study.
|
18769442 |
2009 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
With regard to the Glu298Asp polymorphism in NOS3, the odds ratio for the presence of hypertension in individuals having the Glu/Glu genotype of NOS3 when compared with those having the other genotypes (Asp/Asp and Asp/Glu) was 2.79.
|
19373110 |
2009 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
However, in hypoxic conditions, eNOS phosphorylation was reduced in both the WT and SMP30-deficient mice with no differences in Akt phosphorylation.Our study demonstrated that SMP30 is involved in the development of hypoxia-induced pulmonary hypertension by impairment of eNOS activity.
|
31735783 |
2019 |
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Quantification of monocyte ecNOS mRNA and NO metabolites plasma levels from patients and controls (C) demonstrated NO system upregulation in patients notwithstanding the hypertension.
|
11112045 |
2000 |
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
The aim of this study was to determine whether Hhcy homocysteinylates endothelial nitric oxide synthase (eNOS) and alters caveolin-1 expression to decrease nitric oxide bioavailability, causing hypertension and renal dysfunction.
|
30778103 |
2019 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
Decreased level of BDNF is observed in depression and its connection to hypertension has also been demonstrated with affecting the arterial baroreceptors, renin-angiotensin system and endothelial nitric oxide synthase.
|
30767081 |
2019 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
CTD_human |
Insulin resistance in eNOS(-/-) mice was related specifically to impaired NO synthesis, because in equally hypertensive 1-kidney/1-clip mice (a model of renovascular hypertension), insulin-stimulated glucose uptake was normal.
|
11457755 |
2001 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Associations of NOS3 polymorphisms with hypertension, preeclampsia, stroke, and diabetes remain uncertain.
|
17018701 |
2006 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
CTD_human |
These data highlight the potential utility of eNOS gene therapy in the treatment of hypertension and insulin resistance.
|
19008412 |
2009 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The results of the present study support that homozygosity for +G894T (E298D) in NOS3 is a genetic risk factor for the development of LVH in patients with hypertension.
|
19132956 |
2009 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Although endothelial nitric oxide synthase (eNOS) haplotypes have been associated with hypertension, it is unknown whether eNOS genotypes/haplotypes are associated with resistance to antihypertensive therapy.
|
17082721 |
2006 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Previous studies regarding endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism focused upon its relation to hypertension.
|
17594145 |
2007 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The endothelial nitric oxide synthase (eNOS) (4a/b) gene polymorphism contributes to coronary heart disease and hypertension risk.
|
12923396 |
2003 |
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Given the vasodilatory role of the eNOS gene product, it is possible that the linkage recently reported for eNOS reflects its relationship with hypertension rather than preeclampsia.
|
10464002 |
1999 |
Hypertensive disease
|
0.700 |
Therapeutic
|
group |
CTD_human |
These data highlight the potential utility of eNOS gene therapy in the treatment of hypertension and insulin resistance.
|
19008412 |
2009 |
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
It was found that the myocardial infarction combined with hypertension group had a much higher serum ADMA level and relatively low levels of eNOS and NO compared to those of the other three groups; the myocardial infarction group and the hypertension group had a much higher serum ADMA level compared to that of the healthy control group and the two groups had much lower levels of eNOS and NO.
|
28337882 |
2017 |
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Also, EGb761 inhibited hypertension with hypercholesterolemia-induced decrease in endothelial nitric oxide synthase (eNOS) protein expression and increase in the protein expressions of inducible NO synthase (iNOS), TNF-α, IL-6 and IL-1β in the kidney tissues.
|
28915536 |
2017 |
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Reduced eNOS activity could mediate an increased stroke risk through hypertension or independent of hypertension through abnormal vasomotor responses, promoting atherogenesis, or increased platelet adhesion and aggregation.
|
9731617 |
1998 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
A role for NOS3 in onset of essential hypertension (HT) is, however, controversial.
|
10981549 |
2000 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Gene polymorphisms of endothelial nitric oxide synthase enzyme associated with pulmonary hypertension in patients with COPD.
|
14682408 |
2003 |